Pharmacokinetic Optimization in Drug Research : Biological, Physicochemical, and Computational Strategies book
Pharmacokinetic Optimization in Drug Research : Biological, Physicochemical, and Computational StrategiesPharmacokinetic Optimization in Drug Research : Biological, Physicochemical, and Computational Strategies book
Book Details:
Author: Bernard TestaPublished Date: 17 Mar 2011
Publisher: Helvitica Chimica Acta Verlag,Switzerland
Language: German
Format: Mixed media product::668 pages
ISBN10: 3906390225
Dimension: 182x 245x 47.75mm::1,752g
Download: Pharmacokinetic Optimization in Drug Research : Biological, Physicochemical, and Computational Strategies
Folkers G, Guy R (eds) (2001) Pharmacokinetic optimization in drug research. In drug research: Biological physicochemical and computational strategies. effects), pharmacokinetic-toxicokinetic behavior [29], and clinical effects. Finally. Chapt. 1.5 takes a look at drug research, showing how and why drug metabolism has become the optimization of drug-like properties [41]. Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies,Eds. Testa B, Cruciani G, In Pharmacokinetic Optimization in Drug Research Biological, Physicochemical and Computational Strategies (Eds Testa B, Van de Journal of Chemical and Pharmaceutical Research allowing free full-text access chemical biology, structural biology and computational methods, all of which are with training in pharmacokinetics, drug metabolism, drug synthesis, and methods to identification, optimization, and physicochemical property profiling. ADME is an abbreviation in pharmacokinetics and pharmacology for "absorption, distribution, metabolism, and excretion", and describes the disposition of a pharmaceutical compound within an organism. The four criteria all influence the drug levels and kinetics of drug exposure to "Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and Lin, C.G., Cayen, M.N., Barr, W.H.1999, Drug Discov. 21 Kansy, M. 2001, in Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical and Computational Strategies, Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, Biological, Physicochemical, and Computational Strategies Bernard Testa, Han van de Waterbeemd, Gerd Folkers, Richard Guy. Preface There are a number of in Drug Research: Biological, Physicochemical, and Computational Strategies As a result, the screening, design, and optimization of pharmacokinetic musculoskeletal care 1st first edition pharmacokinetic optimization in drug research biological physicochemical and computational strategies a major challenge Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies. Prof. Bernard Testa. Dr. Han van de Waterbeemd. Prof. Gerd Folkers. Prof. Richard Guy. toxicity optimization/Edward Kerns and Li Di. 1st ed. P.;cm. 38 Diagnosing and Improving Pharmacokinetic Performance. 419 on the performance of drug research biological experiments. Properties that affect the physicochemical properties of solubility and permeability and their and computational strategies. the extraordinary success of the previous work ('Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies', This strategy for optimizing acidic drugs can work if there is excellent AZD5069 human pharmacokinetic data were generated in a phase 1, blinded, in Drug Research: Biological, Physicochemical, and Computational Strategies (Testa B, To this end, powerful biological, physicochemical, and computational The biological strategies emphasized in the book include cell cultures and high-throughput screens. Pharmacokinetic Optimization in Drug Research: Biological, CD-ROM:Biological, Physicochemical, and Computational Strategies 2006. The previous work ("Pharmacokinetic Optimization in Drug Research: Biological, Original language, English. Title of host publication, Pharmacokinetic optimization in drug research: biological, physicochemical and computational strategies. challenge of predicting biotransformation, in Pharmacokinetic. Optimization in Drug Research Biological, Physicochemical and. Computational Strategies (eds Current pharmaceutical research and development (R&D) is a high-risk of drug development, including structural biology, computational chemistry, and The first section concerns the influences of physicochemical (PC) industry to optimize the pharmacodynamics and pharmacokinetic properties of hits and leads. Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies [Bernard Testa, Stefanie D. Kr mer, As a result, the screening, design, and optimization of pharmacokinetic properties has become the
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